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CS-W001157 4
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3-Phenoxycyclobutanecarboxylic acid

  • CAS No. 1263284-46-3

  • Cat. No. CS-0051782
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Phenoxycyclobutanecarboxylic acid|CS-0051782

Structure of 1263284-46-3

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General Information

  • CAS No. 1263284-46-3
  • Cat. No. CS-0051782
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂O₃
  • Molecular Weight 192.21
  • Synonym(s) 3-phenoxy-cyclobutanecarboxylic acid
  • SMILES OC(=O)C1CC(C1)OC1=CC=CC=C1

Description

3-Phenoxycyclobutanecarboxylic acid features a rigid cyclobutane core bearing a phenoxyl group and a carboxylic acid terminus, enabling precise spatial positioning in bioactive molecule design. This scaffold delivers enhanced metabolic stability and favorable lipophilicity profiles, making it valuable for medicinal chemistry applications involving receptor-targeted ligands and enzyme inhibitors.

Application

3-Phenoxycyclobutanecarboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its cyclobutane core provides conformational rigidity, while the phenoxycarbonyl group offers moderate lipophilicity and functional group tolerance. The carboxylic acid moiety facilitates direct derivatization via amide coupling or esterification, supporting efficient access to analog libraries. Bench-stable and readily purified by recrystallization, it functions effectively in standard synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.9286
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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