tert-Butyl (3,3-difluoropiperidin-4-yl)carbamate

Name: tert-Butyl (3,3-difluoropiperidin-4-yl)carbamate
Brand: ChemScene
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CAS No. 1263180-22-8
Cat. No. CS-W001380
Purity≥97%
MDL No.MFCD18791569

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl (3,3-difluoropiperidin-4-yl)carbamate|CS-W001380

Structure of 1263180-22-8

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General Information

CAS No. 1263180-22-8
Cat. No. CS-W001380
Purity ≥97%
MDL No. MFCD18791569
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₈F₂N₂O₂
Molecular Weight 236.26
Synonym(s) 4-(Boc-amino)-3,3-difluoropiperidine
SMILES O=C(OC(C)(C)C)NC1CCNCC1(F)F

Description

tert-Butyl (3,3-difluoropiperidin-4-yl)carbamate is a bench-stable, moisture-tolerant building block featuring a sterically hindered piperidine core with dual fluorine atoms at the 3,3-positions. This configuration enhances metabolic stability and modulates electron density, enabling efficient incorporation into bioactive molecules. The carbamate group facilitates straightforward deprotection under mild acidic conditions, streamlining synthetic workflows in medicinal chemistry and peptide conjugation.

Application

tert-Butyl (3,3-difluoropiperidin-4-yl)carbamate serves as a stable, bench-ready building block for the synthesis of fluorinated piperidine scaffolds. The difluoro substitution at C3 enhances metabolic stability and modulates basicity, while the tert-butoxycarbonyl (Boc) group enables straightforward deprotection under mild acidic conditions. It functions effectively in standard coupling reactions, enabling access to diverse bioactive molecules through iterative functionalization.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 50.36
LogP 1.5083
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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tert-Butyl (3,3-difluoropiperidin-4-yl)carbamate

CAS No. 1263180-22-8

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