tert-Butyl (s)-4-amino-3,3-difluoropiperidine-1-carboxylate

Name: tert-Butyl (s)-4-amino-3,3-difluoropiperidine-1-carboxylate
Brand: ChemScene
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CAS No. 2415515-29-4
Cat. No. CS-0197696
Purity≥98%
MDL No.None

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FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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tert-Butyl (s)-4-amino-3,3-difluoropiperidine-1-carboxylate|CS-0197696

Structure of 2415515-29-4

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General Information

CAS No. 2415515-29-4
Cat. No. CS-0197696
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₈F₂N₂O₂
Molecular Weight 236.26
Synonym(s) (S)-tert-butyl 4-amino-3,3-difluoropiperidine-1-carboxylate
SMILES C(OC(C)(C)C)(=O)N1CC(F)(F)[C@@H](N)CC1

Description

tert-Butyl (S)-4-amino-3,3-difluoropiperidine-1-carboxylate features a stereochemically defined piperidine core with dual fluorine atoms at the 3-position, enhancing metabolic stability and membrane permeability. The tert-butyl ester group enables straightforward deprotection under mild acidic conditions, facilitating integration into bioactive molecules. This scaffold serves as a key building block in medicinal chemistry for targeted CNS and oncology drug discovery.

Application

tert-Butyl (S)-4-amino-3,3-difluoropiperidine-1-carboxylate serves as a versatile chiral building block for the synthesis of fluorinated piperidine derivatives. The protected amine and difluoromethylene group enable selective functionalization and stability under standard reaction conditions. Its structural features facilitate incorporation into bioactive scaffolds, particularly in medicinal chemistry campaigns targeting CNS disorders and kinase inhibitors. The tert-butyl carbamate group offers ease of removal under mild acidic conditions, supporting efficient downstream processing.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 55.56
LogP 1.5898
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

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tert-Butyl (s)-4-amino-3,3-difluoropiperidine-1-carboxylate

CAS No. 2415515-29-4

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