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1-[({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopropane-1-carboxylic acid

  • CAS No. 1263045-62-0

  • Cat. No. CS-0216965
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-[({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopropane-1-carboxylic acid|CS-0216965

Structure of 1263045-62-0

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General Information

  • CAS No. 1263045-62-0
  • Cat. No. CS-0216965
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₁₉NO₄
  • Molecular Weight 337.37
  • Synonym(s) Fmoc-Amcp-OH
  • SMILES O=C(O)C1(CC1)CNC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O

Description

This fluorenylmethoxycarbonyl-protected cyclopropanecarboxylic acid derivative serves as a robust building block for peptide synthesis, featuring a sterically constrained cyclopropyl scaffold that enhances conformational stability. The Fmoc group enables efficient sequential coupling under standard conditions.

Application

1-[(Benzyloxycarbonylamino)methyl]cyclopropane-1-carboxylic acid serves as a robust, bench-stable building block for peptide synthesis, enabling efficient incorporation of cyclopropylalanine derivatives. Its fluoren-9-ylmethoxycarbonyl (Fmoc) protection offers high deprotection fidelity and excellent solubility in organic solvents, facilitating purification and compatibility with standard solid-phase protocols. The cyclopropane carboxylic acid moiety provides conformational rigidity and enhanced metabolic stability, making it valuable for constructing bioactive peptidomimetics and pharmaceutical scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P233-P260-P261-P264-P271-P280-P302+P352-P304+P340-P340-P362-P403-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   3.3899
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   5

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