Fmoc-4-Amc-OH

Name: Fmoc-4-Amc-OH
Brand: ChemScene
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CAS No. 188715-40-4
Cat. No. CS-0187427
Purity≥96%
MDL No.MFCD01862347

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 188715-40-4

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General Information

CAS No. 188715-40-4
Cat. No. CS-0187427
Purity ≥96%
MDL No. MFCD01862347
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₃H₂₅NO₄
Molecular Weight 379.45
Synonym(s) FMOC-(4-AMINOMETHYL)-CYCLOHEXANE CARBOXYLIC ACID
SMILES O=C(O)C1CCC(CC1)CNC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O

Description

Fmoc-4-Amc-OH is a fluorogenic reporter for protease assay development, featuring a coumarin-based quencher and a cleavable Fmoc-protected amine. This construct enables real-time detection of enzymatic activity through fluorescence recovery upon proteolytic cleavage. Designed for high sensitivity in kinetic studies, the compound integrates readily into peptide substrates and maintains stability under standard handling conditions.

Application

Fmoc-4-Amc-OH serves as a versatile building block in peptide synthesis and fluorescent probe development. The Fmoc group enables efficient N-terminal protection and orthogonal deprotection, while the 4-amino-methylcoumarin (Amc) moiety provides a sensitive fluorophore for real-time monitoring of enzymatic cleavage. Its stability under standard solid-phase conditions and ease of purification make it ideal for constructing bioactive peptides and protease substrates.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 75.63
LogP 4.4161
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 5

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Fatty ring compounds Cyclohexane compounds

Key Words

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Fmoc-4-Amc-OH

CAS No. 188715-40-4

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