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(R)-morpholine-2-carbonitrile hydrochloride

  • CAS No. 1262409-78-8

  • Cat. No. CS-0652638
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R)-morpholine-2-carbonitrile hydrochloride|CS-0652638

Structure of 1262409-78-8

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General Information

  • CAS No. 1262409-78-8
  • Cat. No. CS-0652638
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉ClN₂O
  • Molecular Weight 148.59
  • Synonym(s) (R)-2-cyanoMorpholine (hydrochloride)
  • SMILES N#C[C@@H]1OCCNC1.Cl

Description

(R)-morpholine-2-carbonitrile hydrochloride features a chiral morpholine scaffold with a nitrile group at the 2-position, delivering enhanced solubility and stability under standard conditions. This bench-stable derivative facilitates efficient incorporation into synthetic sequences requiring polar, nitrogen-rich motifs.

Application

(R)-Morpholine-2-carbonitrile (hydrochloride) serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to nitrogen-containing heterocycles. Its morpholine core offers favorable solubility and metabolic stability, while the nitrile group facilitates downstream transformations including hydrolysis to amides or acids, and conjugate additions. The hydrochloride salt enhances bench stability and simplifies purification, making it well-suited for scalable synthesis and high-throughput screening campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   45.05
  • LogP   -0.07982
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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