4-Chloro-6-methoxypyridin-3-amine

Name: 4-Chloro-6-methoxypyridin-3-amine
Brand: ChemScene
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CAS No. 1261884-16-5
Cat. No. CS-0334624
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Chloro-6-methoxypyridin-3-amine|CS-0334624

Structure of 1261884-16-5

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Description

4-Chloro-6-methoxypyridin-3-amine features a pyridine core functionalized with a chloro group at C4 and a methoxy substituent at C6, creating a uniquely electron-deficient heterocyclic scaffold. This arrangement enables selective coupling reactions in medicinal chemistry, particularly in the synthesis of kinase inhibitors and antiviral agents. The compound exhibits bench-stable handling under standard conditions and integrates efficiently into diverse reaction cascades.

Application

4-Chloro-6-methoxypyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds. The chloro group facilitates nucleophilic substitution reactions, while the methoxy and amine functionalities provide orthogonal handles for further functionalization. Its bench-stable nature and compatibility with standard coupling protocols make it well-suited for modular synthesis of bioactive molecules.

General Information

CAS No. 1261884-16-5
Cat. No. CS-0334624
Purity ≥95%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂O
Molecular Weight 158.59
Synonym(s) None
SMILES ClC1=CC(OC)=NC=C1N

Computational Chemistry Data

TPSA 48.14
LogP 1.3258
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Chloro-6-methoxypyridin-3-amine

CAS No. 1261884-16-5

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