3-Hydroxy-5-(trifluoromethoxy)benzaldehyde

Name: 3-Hydroxy-5-(trifluoromethoxy)benzaldehyde
Brand: ChemScene
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CAS No. 1261852-80-5
Cat. No. CS-0161087
Purity≥98%
MDL No.MFCD18397429

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Hydroxy-5-(trifluoromethoxy)benzaldehyde|CS-0161087

Structure of 1261852-80-5

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Description

3-Hydroxy-5-(trifluoromethoxy)benzaldehyde features a hydroxyl group flanked by a trifluoromethoxy substituent and an aldehyde moiety, creating a uniquely electron-deficient aromatic scaffold. This combination enables selective coupling in synthetic transformations, particularly in the construction of bioactive heterocycles and advanced intermediates for pharmaceutical development. The molecule exhibits enhanced solubility in polar organic solvents and maintains stability under standard bench conditions.

Application

3-Hydroxy-5-(trifluoromethoxy)benzaldehyde serves as a versatile building block in medicinal chemistry and materials science, enabling the synthesis of functionalized heterocycles and bioactive scaffolds. Its ortho-hydroxyl and trifluoromethoxy groups provide complementary reactivity for coupling reactions, while the aldehyde functionality facilitates imine formation and oxidative transformations. Bench-stable and compatible with standard purification protocols, it supports scalable synthesis in multi-step routes.

General Information

CAS No. 1261852-80-5
Cat. No. CS-0161087
Purity ≥98%
MDL No. MFCD18397429
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅F₃O₃
Molecular Weight 206.12
Synonym(s) None
SMILES O=CC1=CC(OC(F)(F)F)=CC(O)=C1

Computational Chemistry Data

TPSA 46.53
LogP 2.1033
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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3-Hydroxy-5-(trifluoromethoxy)benzaldehyde

CAS No. 1261852-80-5

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