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Structure of 1261843-53-1
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3-Ethyl-5-fluorobenzoic acid features a fluorine atom at the para position relative to the carboxylic acid, enhancing electron withdrawal and metabolic stability. The ethyl substituent at the ortho position provides steric modulation and improved solubility in organic solvents. This scaffold integrates readily into pharmaceutical intermediates and functional materials requiring controlled polarity and reactivity under standard conditions.
3-Ethyl-5-fluorobenzoic acid serves as a versatile building block for pharmaceutical and agrochemical synthesis, offering a fluorinated aromatic core with orthogonal functional handles. Its carboxylic acid group enables direct amidation, esterification, or coupling reactions, while the fluoro substituent enhances metabolic stability and modulates electronic properties. The ethyl group provides steric and lipophilic tuning, facilitating optimization of compound solubility and membrane permeability in medicinal chemistry campaigns. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: