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CS-W001157 4
Total: USD 88.00

(3-Fluoro-5-iodophenyl)methanol

  • CAS No. 1261837-87-9

  • Cat. No. CS-0379574
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3-Fluoro-5-iodophenyl)methanol|CS-0379574

Structure of 1261837-87-9

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General Information

  • CAS No. 1261837-87-9
  • Cat. No. CS-0379574
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FIO
  • Molecular Weight 252.02
  • Synonym(s) None
  • SMILES OCC1=CC(I)=CC(F)=C1

Description

(3-Fluoro-5-iodophenyl)methanol features a fluorinated aromatic ring paired with a reactive benzyl alcohol group, enabling direct functionalization in cross-coupling and derivatization workflows. The electron-withdrawing fluorine substituent enhances regioselectivity, while the iodine moiety supports palladium-catalyzed transformations. This bench-stable reagent integrates efficiently into complex molecule synthesis.

Application

(3-Fluoro-5-iodophenyl)methanol serves as a versatile building block in cross-coupling chemistry, enabling efficient Suzuki and Negishi reactions due to its stable aryl iodide functionality. The pendant alcohol group provides a handle for derivatization or protection, while the meta-fluoro substituent offers orthogonal reactivity in sequential transformations. Its bench-stable nature and compatibility with standard catalytic protocols make it well-suited for the synthesis of complex pharmaceutical intermediates and functionalized heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.9226
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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