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CS-W001157 4
Total: USD 88.00

(2-Fluoro-6-hydroxyphenyl)boronic acid

  • CAS No. 1256345-60-4

  • Cat. No. CS-0043300
  • Purity≥95%
  • MDL No.MFCD17214242

*For research and further manufacturing use only, not for direct human use.

(2-Fluoro-6-hydroxyphenyl)boronic acid|CS-0043300

Structure of 1256345-60-4

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General Information

  • CAS No. 1256345-60-4
  • Cat. No. CS-0043300
  • Purity ≥95%
  • MDL No. MFCD17214242
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BFO₃
  • Molecular Weight 155.92
  • Synonym(s) 2-Fluoro-6-hydroxyphenylboronic acid
  • SMILES OB(C1=C(O)C=CC=C1F)O

Description

This boronate moiety features a strategically positioned fluorine atom and hydroxyl group, enabling enhanced stability and selective coupling in Suzuki-Miyaura reactions. The ortho-hydroxy substitution facilitates in situ ligand formation, improving reactivity under mild conditions while maintaining bench-stable handling properties.

Application

(2-Fluoro-6-hydroxyphenyl)boronic acid serves as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient access to fluorinated aryl scaffolds. The ortho-fluoro and phenolic hydroxyl groups provide enhanced reactivity and directing effects in transition-metal-catalyzed transformations. Its bench-stable nature and compatibility with common reaction conditions facilitate straightforward incorporation into complex molecular architectures, particularly in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -0.7889
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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