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CS-W001157 4
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7-(Difluoromethyl)quinoline

  • CAS No. 1261728-71-5

  • Cat. No. CS-0037130
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-(Difluoromethyl)quinoline|CS-0037130

Structure of 1261728-71-5

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General Information

  • CAS No. 1261728-71-5
  • Cat. No. CS-0037130
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇F₂N
  • Molecular Weight 179.17
  • Synonym(s) 7-(Difluoromethyl)Quinoline(WXC01613)
  • SMILES C1=CC2=C(C=C(C=C2)C(F)F)N=C1

Description

7-(Difluoromethyl)quinoline is a fluorinated heterocyclic scaffold featuring a difluoromethyl group at the 7-position of quinoline. This substitution imparts enhanced electron-withdrawing character and metabolic stability, enabling its use in medicinal chemistry for targeted kinase inhibition and as a bioisostere in drug design.

Application

7-(Difluoromethyl)quinoline serves as a valuable building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group into bioactive scaffolds. Its quinoline core provides a rigid, planar framework with favorable pharmacokinetic properties, while the difluoromethyl substituent offers enhanced metabolic stability and modulated lipophilicity. The functional group exhibits good bench stability and compatibility with standard coupling reactions, facilitating efficient derivatization in late-stage functionalization strategies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.1724
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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