2-Methyl-7-(trifluoromethyl)quinoline

Name: 2-Methyl-7-(trifluoromethyl)quinoline
Brand: ChemScene
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CAS No. 324-32-3
Cat. No. CS-0042689
Molecule weight211.18
Purity≥97%
MDL No.MFCD11108688

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Methyl-7-(trifluoromethyl)quinoline|CS-0042689

Structure of 324-32-3

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General Information

CAS No. 324-32-3
Cat. No. CS-0042689
Purity ≥97%
MDL No. MFCD11108688
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₈F₃N
Molecular Weight 211.18
Synonym(s) N-(4-IODO-2-PYRIDINYL)ACETAMIDE
SMILES CC1=NC2=C(C=C1)C=CC(=C2)C(F)(F)F

Description

2-Methyl-7-(trifluoromethyl)quinoline features a sterically accessible quinoline core enhanced by electron-withdrawing trifluoromethyl and methyl groups. This combination imparts high stability and favorable electronic properties, enabling efficient integration into catalytic systems, ligand frameworks, and advanced pharmaceutical scaffolds under standard bench conditions.

Application

2-Methyl-7-(trifluoromethyl)quinoline serves as a versatile scaffold in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its electron-deficient quinoline core, combined with orthogonal functional groups, facilitates diverse transformations including palladium-catalyzed couplings and electrophilic substitutions. The trifluoromethyl group enhances metabolic stability and membrane permeability, while the methyl substituent provides a handle for further derivatization. Bench-stable and readily purified by chromatography, it functions effectively in high-throughput synthesis workflows.

Synthesis

Route1
- 123-73-9
- 98-16-8
- ~29%
- In-stock
  
  324-32-3
References
- ARRAY BIOPHARMA INC.; BLAKE, James, F; DELISLE, Robert, Kirk; DE MEESE, Lisa, A.; GRAHAM, James, M.; LE HUEROU, Yvan; LYON, Michael; ROBINSON, John, E.; WALLACE, Eli, M.; WANG, Bin; XU, Rui Patent: WO2012/154274 A1, 2012 ; Location in patent: Page/Page column 87-88 ; WO 2012/154274 A1
Route2
- 98-16-8
- 123-73-9
- ~61%
- In-stock
  
  324-32-3
References
- Polanski, Jaroslaw; Zouhiri, Fatima; Jeanson, Laurence; Desmaele, Didier; D'Angelo, Jean; Mouscadet, Jean-Francois; Gieleciak, Rafal; Gasteiger, Johann; Le Bret, Marc Journal of Medicinal Chemistry, 2002 , vol. 45, # 21 p. 4647 - 4654

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 12.89
LogP 3.56202
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

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2-Methyl-7-(trifluoromethyl)quinoline

CAS No. 324-32-3

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