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CS-W001157 4
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tert-Butyl 3-bromopicolinate

  • CAS No. 1260807-49-5

  • Cat. No. CS-0041373
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3-bromopicolinate|CS-0041373

Structure of 1260807-49-5

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General Information

  • CAS No. 1260807-49-5
  • Cat. No. CS-0041373
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂BrNO₂
  • Molecular Weight 258.11
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)C1=NC=CC=C1Br

Description

tert-Butyl 3-bromopicolinate features a brominated picolinate ester scaffold with a sterically hindered tert-butyl group, enhancing stability and reducing side reactivity. This bench-stable reagent facilitates direct coupling in transition metal-catalyzed transformations, enabling efficient access to functionalized heterocycles under mild conditions.

Application

tert-Butyl 3-bromopicolinate serves as a versatile building block for the synthesis of substituted picolines and heterocyclic scaffolds. The bromine atom enables efficient Pd-catalyzed cross-coupling reactions, while the tert-butyl ester group offers stability and convenient deprotection under mild acidic conditions. This compound facilitates the construction of bioactive molecules in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.7994
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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