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Structure of 1260758-52-8
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3-Chloro-7-methoxy-1H-indazole is a heterocyclic scaffold featuring a chlorine atom at the 3-position and a methoxy group at the 7-position, offering enhanced electron-withdrawing character and improved solubility. This configuration enables efficient integration into medicinal chemistry libraries, particularly for kinase inhibitors and bioactive compounds requiring moderate lipophilicity and metabolic stability.
3-Chloro-7-methoxy-1H-indazole serves as a versatile building block in medicinal chemistry, enabling site-selective functionalization via palladium-catalyzed cross-coupling reactions. The chloro group at the 3-position provides high reactivity in Suzuki, Stille, and Negishi couplings, while the 7-methoxy substituent enhances solubility and modulates electronic properties. Bench-stable and readily purified by recrystallization, it functions effectively in the synthesis of bioactive indazole derivatives and heterocyclic scaffolds relevant to kinase inhibitor development.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501
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Lot numbers can be found on the outside label of a product: