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CS-W001157 4
Total: USD 88.00

5-Phenylmorpholin-3-one

  • CAS No. 1260672-03-4

  • Cat. No. CS-W003896
  • Molecule weight177.20
  • Purity≥98%
  • MDL No.MFCD18250283

*For research and further manufacturing use only, not for direct human use.

5-Phenylmorpholin-3-one|CS-W003896

Structure of 1260672-03-4

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General Information

  • CAS No. 1260672-03-4
  • Cat. No. CS-W003896
  • Purity ≥98%
  • MDL No. MFCD18250283
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁NO₂
  • Molecular Weight 177.20
  • Synonym(s) 5-phenyl-3-morpholinone
  • SMILES O=C1NC(C2=CC=CC=C2)COC1

Description

5-Phenylmorpholin-3-one features a rigid, electron-deficient heterocyclic core that integrates seamlessly into kinase inhibitor scaffolds. The phenyl substituent enhances π-stacking interactions in target binding pockets, while the ketone group provides a key hydrogen bond acceptor site. This compound serves as a high-potency pharmacophore in targeted therapeutic development.

Application

5-Phenylmorpholin-3-one serves as a versatile scaffold in medicinal chemistry, enabling efficient access to bioactive heterocycles through standard functionalization at the C5 position. Its morpholinone core exhibits favorable stability and solubility, facilitating downstream transformations such as nucleophilic substitution and coupling reactions. The phenyl substituent enhances π-stacking potential and modulates lipophilicity, supporting its use in lead optimization campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   0.8741
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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