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Structure of 22050-10-8
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5-Phenylpyrrolidin-2-one features a rigid, electron-deficient pyrrolidinone core fused to a phenyl ring, enabling robust integration into bioactive scaffolds. This bench-stable, moisture-tolerant heterocycle facilitates efficient coupling in medicinal chemistry workflows, offering enhanced metabolic stability and improved membrane permeability in target-directed synthesis.
5-Phenylpyrrolidin-2-one serves as a versatile scaffold in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its stable pyrrolidinone core exhibits favorable functional group tolerance and facilitates diverse transformations, including N-alkylation, C–H activation, and coupling reactions. The phenyl substituent enhances π-stacking potential and modulates lipophilicity, supporting its use in lead optimization campaigns. This compound functions reliably in standard synthetic workflows, offering ease of handling and purification for scalable applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: