5-Chloro-4-iodopyridin-2-amine

Name: 5-Chloro-4-iodopyridin-2-amine
Brand: ChemScene
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CAS No. 1260667-65-9
Cat. No. CS-0143877
Purity≥98%
MDL No.MFCD18250085

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Chloro-4-iodopyridin-2-amine|CS-0143877

Structure of 1260667-65-9

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General Information

CAS No. 1260667-65-9
Cat. No. CS-0143877
Purity ≥98%
MDL No. MFCD18250085
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄ClIN₂
Molecular Weight 254.46
Synonym(s) 5-Chloro-4-iodo-2-pyridinamine
SMILES NC1=NC=C(Cl)C(I)=C1

Description

5-Chloro-4-iodopyridin-2-amine features a halogenated pyridine core enabling direct functionalization in cross-coupling reactions. The chlorine and iodine substituents offer orthogonal reactivity, facilitating sequential derivatization. This compound serves as a key scaffold for constructing bioactive heterocycles in medicinal chemistry and materials science.

Application

5-Chloro-4-iodopyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The chlorine and iodine substituents allow sequential functionalization, while the pyridin-2-amine moiety provides a handle for further derivatization. This compound exhibits good bench stability and facilitates efficient synthesis of complex heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 1.9218
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Iodide

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Chloro-4-iodopyridin-2-amine

CAS No. 1260667-65-9

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