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Ethyl 2-fluoro-4-pyridineacetate

  • CAS No. 1260666-12-3

  • Cat. No. CS-0643417
  • Molecule weight183.18
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-fluoro-4-pyridineacetate|CS-0643417

Structure of 1260666-12-3

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General Information

  • CAS No. 1260666-12-3
  • Cat. No. CS-0643417
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀FNO₂
  • Molecular Weight 183.18
  • Synonym(s) Ethyl 2-fluoro-4-pyridineacetate
  • SMILES O=C(OCC)CC1=CC(F)=NC=C1

Description

Ethyl 2-fluoro-4-pyridineacetate features a fluorinated pyridine ring paired with an ester-functionalized side chain, enabling direct incorporation into synthetic routes requiring electron-deficient heterocyclic motifs. This bench-stable intermediate integrates readily into cross-coupling and functionalization cascades, offering predictable reactivity under standard conditions.

Application

Ethyl 2-fluoro-4-pyridineacetate serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated pyridine-containing scaffolds. Its ester functionality facilitates downstream transformations such as hydrolysis, reduction, or coupling reactions, while the ortho-fluoropyridine moiety provides enhanced metabolic stability and tunable electronic properties. The compound exhibits good bench stability and is compatible with standard synthetic protocols, making it valuable for the construction of bioactive heterocycles and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.3263
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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