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Structure of 1260664-44-5
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Tert-butyl 3-(chlorosulfonyl)piperidine-1-carboxylate is a bench-stable, moisture-tolerant reagent featuring a chlorosulfonyl group at the piperidine 3-position. This electrophilic handle enables selective sulfonation of nucleophiles, streamlining access to functionalized piperidine scaffolds in medicinal chemistry and peptide modification workflows.
Tert-butyl 3-(chlorosulfonyl)piperidine-1-carboxylate serves as a versatile building block for the synthesis of sulfonamide-containing heterocycles and piperidine-based scaffolds. The chlorosulfonyl group enables efficient derivatization via nucleophilic substitution, facilitating the introduction of diverse amine functionalities. Its tert-butyl carbamate protection offers stability under basic conditions and allows for straightforward deprotection during late-stage functionalization. This reagent is particularly valuable in medicinal chemistry workflows requiring orthogonally protected piperidines with high synthetic flexibility.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3265
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P280-P301+P330+P331-P304+P340
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Lot numbers can be found on the outside label of a product: