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7-Bromo-1H-pyrrolo[3,2-c]pyridine-3-carbonitrile

  • CAS No. 1260387-11-8

  • Cat. No. CS-0108815
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Bromo-1H-pyrrolo[3,2-c]pyridine-3-carbonitrile|CS-0108815

Structure of 1260387-11-8

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General Information

  • CAS No. 1260387-11-8
  • Cat. No. CS-0108815
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄BrN₃
  • Molecular Weight 222.04
  • Synonym(s) 7-Bromo-3-cyano-5-azaindole
  • SMILES N#CC1=CNC2=C1C=NC=C2Br

Description

7-Bromo-1H-pyrrolo[3,2-c]pyridine-3-carbonitrile is a heterocyclic building block featuring a bromine at the 7-position and a nitrile group at the 3-position. This combination enables direct functionalization via cross-coupling or nucleophilic substitution, delivering access to diverse pyrrolopyridine derivatives for medicinal chemistry and materials applications. The molecule exhibits bench-stable handling characteristics and compatibility with standard reaction conditions.

Application

7-Bromo-1H-pyrrolo[3,2-c]pyridine-3-carbonitrile serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its bromo and nitrile functionalities. The molecule exhibits excellent bench stability and facilitates efficient derivatization for heterocyclic scaffolds found in kinase inhibitors and CNS-targeted compounds. Its defined regiochemistry supports predictable transformations in multistep synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

  • TPSA   52.47
  • LogP   2.19708
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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