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CS-W001157 4
Total: USD 88.00

(6-Fluoropyridin-2-yl)methanamine dihydrochloride

  • CAS No. 1257535-08-2

  • Cat. No. CS-0043034
  • Purity≥95%
  • MDL No.MFCD16872044
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(6-Fluoropyridin-2-yl)methanamine dihydrochloride|CS-0043034

Structure of 1257535-08-2

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Description

This bench-stable dihydrochloride salt features a fluoropyridine core paired with a primary amine handle, enabling straightforward conjugation and metal coordination. The para-fluorine enhances electrophilicity for nucleophilic substitution, while the protonated amine ensures solubility in polar solvents. Ideal for building bioactive scaffolds and catalyst ligands under standard conditions.

Application

(6-Fluoropyridin-2-yl)methanamine dihydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient construction of fluorinated heterocyclic scaffolds. Its bench-stable dihydrochloride salt form enhances handling and solubility, facilitating direct use in amide couplings, Suzuki-Miyaura cross-couplings, and nucleophilic substitution reactions. The ortho-fluoro group provides a latent site for further functionalization, while the primary amine functions as a key synthetic handle for diversification in API development.

General Information

  • CAS No. 1257535-08-2
  • Cat. No. CS-0043034
  • Purity ≥95%
  • MDL No. MFCD16872044
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉Cl₂FN₂
  • Molecular Weight 199.05
  • Synonym(s) (6-fluoropyridin-2-yl)methanamine,dihydrochloride
  • SMILES NCC1=NC(F)=CC=C1.[H]Cl.[H]Cl

Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.523
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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