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CS-W001157 4
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1H-Pyrazolo[4,3-b]pyridine-6-carboxylic acid

  • CAS No. 1256807-59-6

  • Cat. No. CS-0052508
  • Molecule weight163.13
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1H-Pyrazolo[4,3-b]pyridine-6-carboxylic acid|CS-0052508

Structure of 1256807-59-6

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General Information

  • CAS No. 1256807-59-6
  • Cat. No. CS-0052508
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅N₃O₂
  • Molecular Weight 163.13
  • Synonym(s) 1H-Pyrazolo[4,3-b]pyridine-6-carboxylicacid
  • SMILES OC(=O)C1=CN=C2C=NNC2=C1

Description

1H-Pyrazolo[4,3-b]pyridine-6-carboxylic acid is a heterocyclic scaffold featuring a fused pyrazole-pyridine core with a carboxylic acid group at the 6-position. This structure integrates electron-rich aromatic systems with a polar functional handle, enabling direct conjugation in medicinal chemistry applications. The molecule exhibits enhanced solubility and stability under standard reaction conditions, facilitating its use in drug discovery workflows.

Application

1H-Pyrazolo[4,3-b]pyridine-6-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. Its fused tricyclic core exhibits enhanced metabolic stability and π-conjugation, enabling efficient incorporation into bioactive scaffolds. The carboxylic acid functionality facilitates direct derivatization via amide coupling or esterification, supporting modular synthesis of drug candidates and functionalized polymers. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows.

Synthesis

  • Route1
    • In-stock
      Methyl 1H-pyrazolo[4,3-b]pyridine-6-carboxylate|CS-0049241
      1301214-72-1
    • ~21%
    • In-stock
      1H-Pyrazolo[4,3-b]pyridine-6-carboxylic acid|CS-0052508
      1256807-59-6

    References

    • PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung Patent: WO2011/58473 A1, 2011 ; Location in patent: Page/Page column 34 ;
  • Route2

    References

    • Pfizer Inc Patent: US2012/108619 A1, 2012 ;
  • Route3

    References

    • Pfizer Inc Patent: US2012/108619 A1, 2012 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   78.87
  • LogP   0.6561
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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