6-Chloro-4-methoxypyridin-3-amine

Name: 6-Chloro-4-methoxypyridin-3-amine
Brand: ChemScene
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CAS No. 1256805-54-5
Cat. No. CS-0150447
Purity≥95%
MDL No.MFCD18257796

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Chloro-4-methoxypyridin-3-amine|CS-0150447

Structure of 1256805-54-5

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General Information

CAS No. 1256805-54-5
Cat. No. CS-0150447
Purity ≥95%
MDL No. MFCD18257796
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂O
Molecular Weight 158.59
Synonym(s) 6-Chloro-4-methoxy-2-pyridinecarboxylic acid methyl ester
SMILES COC1=CC(=NC=C1N)Cl

Description

6-Chloro-4-methoxypyridin-3-amine serves as a key heterocyclic scaffold in medicinal chemistry, featuring a chlorinated pyridine core with a methoxy group at C4 and a primary amine at C3. This arrangement enables selective coupling reactions and enhances solubility in polar solvents. The compound exhibits stability under standard bench conditions and functions effectively in the synthesis of kinase inhibitors and other bioactive molecules.

Application

6-Chloro-4-methoxypyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through palladium-catalyzed cross-coupling reactions. Its chlorine and amine functionalities offer orthogonal reactivity for sequential derivatization, while the methoxy group enhances solubility and modulates electronic properties. Bench-stable and readily purified, it functions reliably in standard synthetic workflows for API development and heterocycle functionalization.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 48.14
LogP 1.3258
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-4-methoxypyridin-3-amine

CAS No. 1256805-54-5

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