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Structure of 1256804-49-5
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4-(Difluoromethyl)picolinic acid features a strategically positioned difluoromethyl group on the pyridine ring, enhancing electronic withdrawal and metabolic stability. This electron-deficient heterocycle integrates readily into bioactive scaffolds, enabling direct incorporation into pharmaceutical intermediates and ligand designs through robust coupling protocols under standard conditions.
4-(Difluoromethyl)picolinic acid serves as a versatile building block in medicinal chemistry, enabling the incorporation of a metabolically stable difluoromethyl group into bioactive molecules. Its pyridine carboxylic acid scaffold facilitates direct amidation, esterification, and coupling reactions, while the difluoromethyl moiety imparts enhanced lipophilicity and resistance to oxidative metabolism. The compound exhibits excellent bench stability and compatibility with standard purification techniques, making it ideal for high-throughput synthesis and lead optimization campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: