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CS-W001157 4
Total: USD 88.00

4-Bromo-5-methoxy-2-methylpyridine

  • CAS No. 1256804-48-4

  • Cat. No. CS-0146028
  • Purity≥98%
  • MDL No.MFCD17168572

*For research and further manufacturing use only, not for direct human use.

4-Bromo-5-methoxy-2-methylpyridine|CS-0146028

Structure of 1256804-48-4

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General Information

  • CAS No. 1256804-48-4
  • Cat. No. CS-0146028
  • Purity ≥98%
  • MDL No. MFCD17168572
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BrNO
  • Molecular Weight 202.05
  • Synonym(s) None
  • SMILES CC1=NC=C(OC)C(Br)=C1

Description

4-Bromo-5-methoxy-2-methylpyridine features a pyridine core functionalized with bromo, methoxy, and methyl groups at strategic positions, enabling direct incorporation into cross-coupling reactions. The electron-rich aromatic system enhances reactivity in palladium-catalyzed transformations, while the methoxy and methyl substituents provide steric and electronic modulation. This compound serves as a key building block for pharmaceutical intermediates and advanced materials.

Application

4-Bromo-5-methoxy-2-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined halogen functionality. The methoxy and methyl groups provide orthogonal sites for further functionalization, while the pyridine core offers favorable solubility and stability under standard reaction conditions. Its bench-stable nature and compatibility with diverse transformations make it ideal for constructing complex heterocyclic scaffolds in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.16112
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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