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CS-W001157 4
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2-(2,3-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 1255760-30-5

  • Cat. No. CS-0189398
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(2,3-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0189398

Structure of 1255760-30-5

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General Information

  • CAS No. 1255760-30-5
  • Cat. No. CS-0189398
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅BCl₂O₂
  • Molecular Weight 272.96
  • Synonym(s) 2-(2,3-dichlorophenyl)-5,5-diMethyl-1,3,2-dioxaborinane
  • SMILES CC1(C)C(C)(C)OB(C2=C(C(=CC=C2)Cl)Cl)O1

Description

This boronate ester features a 2,3-dichlorophenyl moiety integrated via a stable dioxaborolane ring, enabling efficient cross-coupling under standard conditions. The tetramethyl substitution enhances solubility and shelf stability while minimizing side reactions during Suzuki-Miyaura transformations.

Application

2-(2,3-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boronate building block for palladium-catalyzed cross-coupling reactions. Its ortho-dichlorophenyl moiety enables direct incorporation into biaryl scaffolds common in pharmaceutical intermediates. The tetramethyl-substituted dioxaborolane core offers enhanced hydrolytic stability and ease of purification, facilitating reliable coupling with aryl halides and triflates under standard reaction conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P363-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   3.2926
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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