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CS-W001157 4
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1-(tert-Butoxycarbonyl)-5,5-difluoropiperidine-3-carboxylic acid

  • CAS No. 1255666-86-4

  • Cat. No. CS-W001366
  • Molecule weight265.25
  • Purity≥97%
  • MDL No.MFCD18433630

*For research and further manufacturing use only, not for direct human use.

1-(tert-Butoxycarbonyl)-5,5-difluoropiperidine-3-carboxylic acid|CS-W001366

Structure of 1255666-86-4

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General Information

  • CAS No. 1255666-86-4
  • Cat. No. CS-W001366
  • Purity ≥97%
  • MDL No. MFCD18433630
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₇F₂NO₄
  • Molecular Weight 265.25
  • Synonym(s) 5,5-Difluoro-1,3-piperidinedicarboxylicacid tert-butyl ester
  • SMILES OC(=O)C1CN(CC(C1)(F)F)C(=O)OC(C)(C)C

Description

This protected piperidine derivative features a difluorinated ring system and a tert-butyl carbamate group, enabling stable incorporation into peptide-based scaffolds. The electron-withdrawing fluorine atoms enhance conformational rigidity and metabolic stability, while the Boc moiety permits selective deprotection during synthetic workflows.

Application

1-(tert-Butoxycarbonyl)-5,5-difluoropiperidine-3-carboxylic acid serves as a valuable building block in medicinal chemistry, enabling the incorporation of a sterically constrained, electron-deficient piperidine scaffold. The difluoro substitution at C5 enhances metabolic stability and modulates basicity, while the Boc group provides orthogonal protection for amine functionality. This compound facilitates efficient coupling reactions and subsequent deprotection, supporting streamlined synthesis of fluorinated heterocyclic motifs common in bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.9633
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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