6-Fluoroquinolin-5-amine

Name: 6-Fluoroquinolin-5-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1251032-63-9
Cat. No. CS-0128177
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 1251032-63-9

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General Information

CAS No. 1251032-63-9
Cat. No. CS-0128177
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₇FN₂
Molecular Weight 162.16
Synonym(s) None
SMILES NC1=C2C=CC=NC2=CC=C1F

Description

6-Fluoroquinolin-5-amine features a fluorine atom at the 6-position and a primary amine at the 5-position of the quinoline scaffold, delivering enhanced electron-withdrawing character and improved solubility in polar solvents. This combination enables efficient coupling reactions in medicinal chemistry applications, particularly in the synthesis of kinase inhibitors and fluorescent probes.

Application

6-Fluoroquinolin-5-amine serves as a versatile building block in medicinal chemistry, enabling direct incorporation into kinase inhibitors and other bioactive heterocycles. Its fluorinated quinoline core offers enhanced metabolic stability and improved membrane permeability. The amine functionality facilitates coupling reactions (e.g., Suzuki, Buchwald–Hartwig), while the fluorine substituent provides orthogonal reactivity for downstream modifications. Bench-stable and readily purified by chromatography or recrystallization, it functions reliably in multi-step syntheses of pharmaceutical candidates.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 38.91
LogP 1.9561
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

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6-Fluoroquinolin-5-amine

CAS No. 1251032-63-9

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