tert-Butyl 5-oxo-2-azaspiro[3.3]heptane-2-carboxylate

Name: tert-Butyl 5-oxo-2-azaspiro[3.3]heptane-2-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 1251020-88-8
Cat. No. CS-0048177
Purity≥96%
MDL No.MFCD17016196

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl 5-oxo-2-azaspiro[3.3]heptane-2-carboxylate|CS-0048177

Structure of 1251020-88-8

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Description

tert-Butyl 5-oxo-2-azaspiro[3.3]heptane-2-carboxylate is a sterically hindered spirocyclic scaffold featuring a ketone and a protected amine within a rigid bicyclic framework. This bench-stable, moisture-tolerant building block enables efficient access to complex nitrogen-containing architectures in medicinal chemistry and natural product synthesis.

Application

tert-Butyl 5-oxo-2-azaspiro[3.3]heptane-2-carboxylate serves as a versatile spirocyclic building block for the synthesis of nitrogen-containing heterocycles, particularly in medicinal chemistry and natural product derivatization. The molecule combines a stable tert-butyl ester with a ketone-functionalized spirocyclic scaffold, enabling selective transformations at both the carbonyl and amine sites. Its bench-stable nature and compatibility with standard reductive amination, alkylation, and coupling protocols facilitate efficient access to complex scaffolds.

General Information

CAS No. 1251020-88-8
Cat. No. CS-0048177
Purity ≥96%
MDL No. MFCD17016196
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₇NO₃
Molecular Weight None
Synonym(s) 5-Oxo-2-azaspiro[3.3]heptane-2-carboxylicacid tert-butyl ester
SMILES CC(C)(C)OC(=O)N1CC2(CCC2=O)C1

Computational Chemistry Data

TPSA 46.61
LogP 1.5864
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Building Blocks Skeleton Spirol Rings compounds

Key Words

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tert-Butyl 5-oxo-2-azaspiro[3.3]heptane-2-carboxylate

CAS No. 1251020-88-8

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