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8-Boc-8-Azaspiro[4.5]decane-2-amino

  • CAS No. 1251010-90-8

  • Cat. No. CS-0055680
  • Purity≥97%
  • MDL No.MFCD18791679

*For research and further manufacturing use only, not for direct human use.

8-Boc-8-Azaspiro[4.5]decane-2-amino|CS-0055680

Structure of 1251010-90-8

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General Information

  • CAS No. 1251010-90-8
  • Cat. No. CS-0055680
  • Purity ≥97%
  • MDL No. MFCD18791679
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₆N₂O₂
  • Molecular Weight 254.37
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC2(CC1)CCC(N)C2

Description

tert-Butyl 2-amino-8-azaspiro[4.5]decane-8-carboxylate features a rigid spirocyclic scaffold with a tertiary amine and protected amine functionality, enabling direct incorporation into complex heterocycles. The tert-butyl ester group offers enhanced stability and ease of deprotection under mild acidic conditions. This compound serves as a key intermediate in the synthesis of bioactive nitrogen-rich architectures.

Application

tert-Butyl 2-amino-8-azaspiro[4.5]decane-8-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry, enabling efficient access to nitrogen-rich heterocycles. The protected amine and carboxylate functionalities offer orthogonal reactivity, facilitating diverse functionalization and downstream derivatization. Its bench-stable nature and compatibility with standard coupling and reduction protocols make it well-suited for iterative synthesis in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   2.5149
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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