8-Bromo-4-chloroquinazoline

Name: 8-Bromo-4-chloroquinazoline
Brand: ChemScene
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CAS No. 125096-72-2
Cat. No. CS-D0030
Purity≥97%
MDL No.MFCD09738589

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 125096-72-2

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General Information

CAS No. 125096-72-2
Cat. No. CS-D0030
Purity ≥97%
MDL No. MFCD09738589
Storage -20°C, stored under nitrogen, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₄BrClN₂
Molecular Weight 243.49
Synonym(s) None
SMILES ClC1=C2C=CC=C(Br)C2=NC=N1

Description

8-Bromo-4-chloroquinazoline is a heterocyclic compound featuring bromine and chlorine substituents at the 8- and 4-positions of the quinazoline core. This electron-deficient scaffold enables direct incorporation into bioactive molecules, particularly kinase inhibitors and fluorescent probes. The dual halogenation enhances reactivity in palladium-catalyzed cross-coupling reactions, facilitating rapid diversification. Bench-stable and moisture-tolerant, it serves as a robust building block for medicinal chemistry campaigns requiring precise substitution patterns.

Application

8-Bromo-4-chloroquinazoline serves as a versatile building block for the synthesis of bioactive heterocycles, enabling direct functionalization at both the 4- and 8-positions via palladium-catalyzed cross-coupling. Its orthogonal halogen reactivity profile facilitates sequential derivatization, while its bench-stable solid form simplifies handling and purification in medicinal chemistry campaigns.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 3.0457
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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8-Bromo-4-chloroquinazoline

CAS No. 125096-72-2

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