2-Chloro-4-(methoxymethyl)pyridine

Name: 2-Chloro-4-(methoxymethyl)pyridine
Brand: ChemScene
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CAS No. 1249610-72-7
Cat. No. CS-0192314
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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2-Chloro-4-(methoxymethyl)pyridine|CS-0192314

Structure of 1249610-72-7

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General Information

CAS No. 1249610-72-7
Cat. No. CS-0192314
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈ClNO
Molecular Weight 157.60
Synonym(s) None
SMILES COCC1=CC(=NC=C1)Cl

Description

2-Chloro-4-(methoxymethyl)pyridine features a pyridine core functionalized with a chlorine atom at the 2-position and a methoxymethyl group at the 4-position, delivering enhanced reactivity and solubility. This combination enables efficient incorporation into pharmaceutical intermediates and agrochemical scaffolds, where its electron-deficient ring facilitates nucleophilic substitution. The methoxymethyl moiety offers stability under standard conditions while permitting controlled deprotection in late-stage synthesis.

Application

2-Chloro-4-(methoxymethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via cross-coupling and nucleophilic substitution reactions. The chloropyridine moiety provides high reactivity under palladium-catalyzed conditions, while the methoxymethyl group offers orthogonal handle for selective derivatization. Bench-stable and compatible with standard purification protocols, it facilitates the synthesis of complex heterocyclic scaffolds and API intermediates with predictable regioselectivity.

Synthesis

Route1
- In-stock
  
  100704-10-7
- 74-88-4
- ~%
- In-stock
  
  1249610-72-7
References
- DAINIPPON SUMITOMO PHARMA CO., LTD. Patent: US2012/225876 A1, 2012 ; Location in patent: Page/Page column 39 ;
Route2
- In-stock
  
  6313-54-8
- ~%
- In-stock
  
  1249610-72-7
References
- DAINIPPON SUMITOMO PHARMA CO., LTD. Patent: US2012/225876 A1, 2012 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 22.12
LogP 1.8814
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Ether

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-4-(methoxymethyl)pyridine

CAS No. 1249610-72-7

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