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CS-W001157 4
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(1H-Indol-4-yl)methanol

  • CAS No. 1074-85-7

  • Cat. No. CS-0156988
  • Purity≥97%
  • MDL No.MFCD01632220

*For research and further manufacturing use only, not for direct human use.

(1H-Indol-4-yl)methanol|CS-0156988

Structure of 1074-85-7

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General Information

  • CAS No. 1074-85-7
  • Cat. No. CS-0156988
  • Purity ≥97%
  • MDL No. MFCD01632220
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉NO
  • Molecular Weight 147.17
  • Synonym(s) Indole-4-methanol
  • SMILES C1=CC(=C2C=CNC2=C1)CO

Description

(1H-Indol-4-yl)methanol features a benzene-fused indole core with a pendant hydroxymethyl group, delivering a versatile scaffold for synthetic modifications. This bench-stable derivative integrates readily into bioactive molecule design, where the polar methylene alcohol enhances solubility and serves as a handle for further functionalization.

Application

(1H-Indol-4-yl)methanol serves as a versatile building block for indole-based scaffolds, enabling direct functionalization at the C4 position. Its aldehyde functionality facilitates reductive amination, Grignard additions, and coupling reactions with nucleophiles, while maintaining stability under standard bench conditions. The molecule functions effectively in the synthesis of heterocyclic libraries and bioactive compounds, offering straightforward purification and compatibility with common reaction protocols.

Synthesis

  • Route1

    References

    • US2002/91134 A1, ; US 20020091134 A1
  • Route2

    References

    • WO2007/53131 A2, ; Page/Page column 161 ; WO 2007/053131 A2
  • Route3

    References

    • US2002/161237 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   36.02
  • LogP   1.6602
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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