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N,N-Dimethylazetidin-3-amine dihydrochloride

  • CAS No. 124668-49-1

  • Cat. No. CS-W003613
  • Purity≥97%
  • MDL No.MFCD09264378

*For research and further manufacturing use only, not for direct human use.

N,N-Dimethylazetidin-3-amine dihydrochloride|CS-W003613

Structure of 124668-49-1

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General Information

  • CAS No. 124668-49-1
  • Cat. No. CS-W003613
  • Purity ≥97%
  • MDL No. MFCD09264378
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₄Cl₂N₂
  • Molecular Weight 173.08
  • Synonym(s) N,N-dimethylazetidin-3-amine hydrochloride
  • SMILES CN(C)C1CNC1.Cl.Cl

Description

N,N-Dimethylazetidin-3-amine dihydrochloride is a bench-stable, moisture-tolerant heterocyclic amine featuring a strained four-membered ring with two methyl groups on nitrogen. This polar, protonated form enhances solubility in aqueous and polar organic media, enabling efficient incorporation into synthetic intermediates. The tertiary amine moiety facilitates nucleophilic reactivity in coupling reactions and functionalization processes.

Application

N,N-Dimethylazetidin-3-amine dihydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient synthesis of bioactive heterocycles. Its tertiary amine functionality offers excellent solubility and nucleophilicity, facilitating rapid conjugation in amide couplings and reductive amination protocols. The azetidine core provides enhanced metabolic stability and improved pharmacokinetic profiles in drug candidates. Bench-stable and easily handled, it functions reliably in standard reaction workflows, supporting scalable synthesis of targeted API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   0.3634
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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