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3-Bromo-6-methoxypyrazolo[1,5-b]pyridazine

  • CAS No. 1246552-73-7

  • Cat. No. CS-0102090
  • Molecule weight228.05
  • Purity≥97%
  • MDL No.MFCD17677036

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-methoxypyrazolo[1,5-b]pyridazine|CS-0102090

Structure of 1246552-73-7

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General Information

  • CAS No. 1246552-73-7
  • Cat. No. CS-0102090
  • Purity ≥97%
  • MDL No. MFCD17677036
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrN₃O
  • Molecular Weight 228.05
  • Synonym(s) None
  • SMILES COC1=NN2C(C=C1)=C(C=N2)Br

Description

3-Bromo-6-methoxypyrazolo[1,5-b]pyridazine features a brominated pyrazolopyridazine core with a methoxy group at the 6-position, enabling direct functionalization in cross-coupling reactions. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds and serves as a key intermediate for bioactive molecule synthesis under standard conditions.

Application

3-Bromo-6-methoxypyrazolo[1,5-b]pyridazine serves as a versatile heterocyclic building block for medicinal chemistry and agrochemical synthesis. The bromo group enables palladium-catalyzed cross-coupling reactions, while the methoxy substituent offers moderate electron-donating character and facilitates downstream functionalization. Its stability under standard reaction conditions and compatibility with diverse coupling partners make it a practical scaffold for constructing complex nitrogen-containing architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   39.42
  • LogP   1.5004
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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