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CS-W001157 4
Total: USD 88.00

5,6,7,8-Tetrahydroisoquinolin-5-amine hydrochloride

  • CAS No. 1246552-20-4

  • Cat. No. CS-0155365
  • Purity≥97%
  • MDL No.MFCD18253782
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5,6,7,8-Tetrahydroisoquinolin-5-amine hydrochloride|CS-0155365

Structure of 1246552-20-4

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Description

This tetrahydroisoquinoline derivative features a protonated amine moiety enhancing solubility and stability under standard conditions. The saturated ring system imparts conformational rigidity, while the primary amine enables direct functionalization in synthetic sequences. This hydrochloride salt serves as a key intermediate in alkaloid synthesis and medicinal chemistry campaigns requiring a basic nitrogen scaffold with defined stereochemistry.

Application

5,6,7,8-Tetrahydroisoquinolin-5-amine hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to isoquinoline-based scaffolds. Its amine functionality facilitates straightforward derivatization via alkylation, acylation, and reductive amination, while the hydrochloride salt ensures excellent bench stability and ease of handling. This compound functions effectively in standard coupling reactions and supports the synthesis of bioactive molecules requiring nitrogen-rich heterocyclic cores.

General Information

  • CAS No. 1246552-20-4
  • Cat. No. CS-0155365
  • Purity ≥97%
  • MDL No. MFCD18253782
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃ClN₂
  • Molecular Weight 184.67
  • Synonym(s) 5,6,7,8-TETRAHYDROISOQUINOLIN-5-AMINE HCL
  • SMILES C1CC2=CN=CC=C2C(C1)N.Cl

Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.8395
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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