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CS-W001157 4
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(S)-4-Fluoro-2,3-dihydrobenzofuran-3-amine

  • CAS No. 1213519-46-0

  • Cat. No. CS-0162030
  • Molecule weight153.15
  • Purity≥97%
  • MDL No.MFCD14562612

*For research and further manufacturing use only, not for direct human use.

(S)-4-Fluoro-2,3-dihydrobenzofuran-3-amine|CS-0162030

Structure of 1213519-46-0

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General Information

  • CAS No. 1213519-46-0
  • Cat. No. CS-0162030
  • Purity ≥97%
  • MDL No. MFCD14562612
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈FNO
  • Molecular Weight 153.15
  • Synonym(s) (3S)-4-Fluoro-2,3-dihydrobenzo[b]furan-3-ylamine
  • SMILES N[C@@H]1COC2=CC=CC(F)=C12

Description

(S)-4-Fluoro-2,3-dihydrobenzofuran-3-amine is a chiral heterocyclic amine featuring a fluorinated benzofuran scaffold. This bench-stable compound integrates seamlessly into medicinal chemistry campaigns requiring stereocontrolled access to bioactive scaffolds. The pendant primary amine enables direct derivatization, while the fluorine substituent enhances metabolic stability and modulates electronic properties.

Application

(S)-4-Fluoro-2,3-dihydrobenzofuran-3-amine serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of fluorinated heterocyclic scaffolds relevant to CNS-targeted therapeutics. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient derivatization. The amine functionality supports straightforward functional group interconversions, while the fused dihydrobenzofuran core provides rigidity and defined stereochemistry, enhancing target selectivity in lead optimization campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.2179
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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