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CS-W001157 4
Total: USD 88.00

(2-Methyl-4-(trifluoromethyl)thiazol-5-yl)methanamine

  • CAS No. 1283720-60-4

  • Cat. No. CS-0162337
  • Purity≥95%
  • MDL No.MFCD15071388

*For research and further manufacturing use only, not for direct human use.

(2-Methyl-4-(trifluoromethyl)thiazol-5-yl)methanamine|CS-0162337

Structure of 1283720-60-4

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General Information

  • CAS No. 1283720-60-4
  • Cat. No. CS-0162337
  • Purity ≥95%
  • MDL No. MFCD15071388
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇F₃N₂S
  • Molecular Weight 196.19
  • Synonym(s) C-(2-Methyl-4-trifluoroMethyl-thiazol-5-yl)-MethylaMine
  • SMILES NCC1=C(C(F)(F)F)N=C(C)S1

Description

This bench-stable thiazole derivative features a trifluoromethyl group enhancing electron-withdrawal and a methyl substituent optimizing steric profile. The pendant primary amine enables direct coupling in medicinal chemistry, serving as a key scaffold for kinase inhibitors and bioactive heterocycles.

Application

(2-Methyl-4-(trifluoromethyl)thiazol-5-yl)methanamine serves as a versatile building block for medicinal chemistry, enabling efficient access to thiazole-based scaffolds. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the primary amine facilitates conjugation in standard coupling reactions. The compound exhibits bench stability, ease of purification, and compatibility with diverse functional groups, making it well-suited for iterative synthesis and lead optimization workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.92902
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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