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Structure of 1243395-68-7
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4-Hydroxy-2-(trifluoromethyl)benzaldehyde features a phenolic hydroxyl group and a strongly electron-withdrawing trifluoromethyl substituent positioned ortho to the aldehyde. This combination imparts enhanced reactivity in nucleophilic addition reactions while maintaining bench-stable handling characteristics under standard conditions.
4-Hydroxy-2-(trifluoromethyl)benzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to bioactive heterocycles. Its ortho-hydroxyl and trifluoromethyl groups provide enhanced solubility, metabolic stability, and favorable electronic effects for downstream functionalization. The aldehyde group facilitates reliable reductive amination, condensation, and Ullmann-type coupling reactions. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step synthetic sequences requiring high functional group tolerance and predictable reactivity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: