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CS-W001157 4
Total: USD 88.00

1-(4-Hydroxy-2-(trifluoromethyl)phenyl)ethanone

  • CAS No. 220227-53-2

  • Cat. No. CS-0042917
  • Purity≥98%
  • MDL No.MFCD01091004
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(4-Hydroxy-2-(trifluoromethyl)phenyl)ethanone|CS-0042917

Structure of 220227-53-2

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Description

This ketone features a trifluoromethyl-substituted phenyl ring conjugated to a benzoyl-like acetyl group, delivering enhanced electron-withdrawing character and improved metabolic stability. The para-hydroxy functionality enables direct coupling in synthetic transformations, while the overall structure exhibits robust bench stability and solubility in common organic solvents, streamlining use in medicinal chemistry and materials synthesis workflows.

Application

1-(4-Hydroxy-2-(trifluoromethyl)phenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its phenolic hydroxyl group offers direct handle for derivatization, while the trifluoromethyl substituent enhances metabolic stability and lipophilicity. The ketone functionality facilitates Grignard additions, reductions, and enolization reactions under standard conditions. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses requiring functional group compatibility and predictable reactivity.

General Information

  • CAS No. 220227-53-2
  • Cat. No. CS-0042917
  • Purity ≥98%
  • MDL No. MFCD01091004
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇F₃O₂
  • Molecular Weight 204.15
  • Synonym(s) 4'-Hydroxy-2'-trifluoromethylacetophenone
  • SMILES OC1=CC(=C(C=C1)C(C)=O)C(F)(F)F

Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.6136
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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