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*For research and further manufacturing use only, not for direct human use.
Structure of 220227-53-2
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This ketone features a trifluoromethyl-substituted phenyl ring conjugated to a benzoyl-like acetyl group, delivering enhanced electron-withdrawing character and improved metabolic stability. The para-hydroxy functionality enables direct coupling in synthetic transformations, while the overall structure exhibits robust bench stability and solubility in common organic solvents, streamlining use in medicinal chemistry and materials synthesis workflows.
1-(4-Hydroxy-2-(trifluoromethyl)phenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its phenolic hydroxyl group offers direct handle for derivatization, while the trifluoromethyl substituent enhances metabolic stability and lipophilicity. The ketone functionality facilitates Grignard additions, reductions, and enolization reactions under standard conditions. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses requiring functional group compatibility and predictable reactivity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: