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CS-W001157 4
Total: USD 88.00

5-Amino-2-bromoisonicotinic acid

  • CAS No. 1242336-80-6

  • Cat. No. CS-0053918
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Amino-2-bromoisonicotinic acid|CS-0053918

Structure of 1242336-80-6

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General Information

  • CAS No. 1242336-80-6
  • Cat. No. CS-0053918
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrN₂O₂
  • Molecular Weight 217.02
  • Synonym(s) 5-Amino-2-bromo-pyridine-4-carboxylic acid
  • SMILES O=C(O)C1=C(N)C=NC(Br)=C1

Description

5-Amino-2-bromoisonicotinic acid features a brominated pyridine core with complementary amino and carboxylic acid functionalities. This combination enables direct coupling in peptide synthesis and facilitates downstream derivatization in medicinal chemistry. The molecule exhibits enhanced solubility in polar solvents and maintains stability under standard bench conditions, simplifying handling in multi-step transformations.

Application

5-Amino-2-bromoisonicotinic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through palladium-catalyzed cross-coupling and electrophilic substitution reactions. Its amino and bromo groups offer orthogonal functionalization potential, while the carboxylic acid facilitates derivatization via amide or ester formation. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis campaigns targeting kinase inhibitors and other pharmaceutical scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   76.21
  • LogP   1.1245
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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