(R)-2-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester

Name: (R)-2-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester
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CAS No. 1240588-01-5
Cat. No. CS-0341842
Purity≥98%
MDL No.None

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(R)-2-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester|CS-0341842

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General Information

CAS No. 1240588-01-5
Cat. No. CS-0341842
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₇F₃N₂O₂
Molecular Weight 254.25
Synonym(s) tert-butyl (R)-2-(trifluoromethyl)piperazine-1-carboxylate
SMILES O=C(N1[C@@H](C(F)(F)F)CNCC1)OC(C)(C)C

Description

(R)-2-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester features a chiral trifluoromethyl-piperazine scaffold with a bench-stable tert-butyl ester handle. This robust, moisture-tolerant building block integrates seamlessly into late-stage functionalization workflows, enabling efficient access to bioactive piperazine derivatives in medicinal chemistry and chemical biology applications.

Application

(R)-2-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester serves as a versatile chiral building block in medicinal chemistry, enabling the efficient construction of trifluoromethylated piperazine scaffolds. Its tert-butyl ester group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. The molecule exhibits robust functional group tolerance and functions effectively in standard coupling reactions, supporting the synthesis of bioactive compounds and API intermediates.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H320
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P362

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Computational Chemistry Data

TPSA 41.57
LogP 1.7576
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

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(R)-2-Trifluoromethyl-piperazine-1-carboxylic acid tert-butyl ester

CAS No. 1240588-01-5

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