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CS-W001157 4
Total: USD 88.00

1-Cyclopropyl-1H-pyrazol-4-amine

  • CAS No. 1240567-18-3

  • Cat. No. CS-0096334
  • Molecule weight123.16
  • Purity≥97%
  • MDL No.MFCD16810881

*For research and further manufacturing use only, not for direct human use.

1-Cyclopropyl-1H-pyrazol-4-amine|CS-0096334

Structure of 1240567-18-3

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General Information

  • CAS No. 1240567-18-3
  • Cat. No. CS-0096334
  • Purity ≥97%
  • MDL No. MFCD16810881
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃
  • Molecular Weight 123.16
  • Synonym(s) None
  • SMILES NC1=CN(C2CC2)N=C1

Description

1-Cyclopropyl-1H-pyrazol-4-amine features a cyclopropyl group attached to the pyrazole nitrogen, enhancing metabolic stability and lipophilicity. This substitution imparts favorable pharmacokinetic properties, making it a valuable scaffold in medicinal chemistry for targeting kinase pathways and GPCR systems.

Application

1-Cyclopropyl-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyrazole-based heterocycles through standard coupling and functionalization reactions. Its cyclopropyl substituent enhances metabolic stability and modulates lipophilicity, while the primary amine facilitates conjugation and derivatization. The compound exhibits good bench stability and is compatible with common reaction conditions, making it suitable for iterative synthetic workflows and library generation.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   0.8002
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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