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CS-W001157 4
Total: USD 88.00

1-Cyclopropyl-1H-pyrazol-3-amine

  • CAS No. 1240565-06-3

  • Cat. No. CS-0052580
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Cyclopropyl-1H-pyrazol-3-amine|CS-0052580

Structure of 1240565-06-3

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General Information

  • CAS No. 1240565-06-3
  • Cat. No. CS-0052580
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃
  • Molecular Weight 123.16
  • Synonym(s) 1-cyclopropylpyrazol-3-amine
  • SMILES NC1=NN(C=C1)C1CC1

Description

1-Cyclopropyl-1H-pyrazol-3-amine features a cyclopropyl group attached to the pyrazole nitrogen, enhancing metabolic stability and membrane permeability. This electron-rich heterocycle integrates readily into medicinal chemistry scaffolds, serving as a key building block for kinase inhibitors and CNS-targeted therapeutics.

Application

1-Cyclopropyl-1H-pyrazol-3-amine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrazole-based scaffolds prevalent in kinase inhibitors and bioactive heterocycles. The primary amine functionality facilitates straightforward derivatization via acylation, alkylation, or coupling reactions, while the cyclopropyl group enhances metabolic stability and modulates lipophilicity. Bench-stable and compatible with standard purification methods, it functions reliably in multi-step syntheses for API development.

Synthesis

  • Route1
    • null|null
      1262669-27-1
    • ~80%
    • In-stock
      1-Cyclopropyl-1H-pyrazol-3-amine|CS-0052580
      1240565-06-3

    References

    • Ji, Nan; Meredith, Erik; Liu, Donglei; Adams, Christopher M.; Artman III, Gerald D.; Jendza, Keith C.; Ma, Fupeng; Mainolfi, Nello; Powers, James J.; Zhang, Chun Tetrahedron Letters, 2010 , vol. 51, # 52 p. 6799 - 6801

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   0.8002
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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