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8-Methyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine

  • CAS No. 1239648-74-8

  • Cat. No. CS-0434503
  • Molecule weight148.17
  • Purity≥97%
  • MDL No.MFCD11846609

*For research and further manufacturing use only, not for direct human use.

8-Methyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine|CS-0434503

Structure of 1239648-74-8

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General Information

  • CAS No. 1239648-74-8
  • Cat. No. CS-0434503
  • Purity ≥97%
  • MDL No. MFCD11846609
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₄
  • Molecular Weight 148.17
  • Synonym(s) None
  • SMILES NC1=NN2C=CC=C(C)C2=N1

Description

8-Methyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine is a bench-stable heterocyclic amine featuring a fused triazolopyridine core with a methyl group at the 8-position. This electron-rich scaffold integrates readily into medicinal chemistry libraries, offering enhanced solubility and metabolic stability. The para-amino functionality enables direct coupling in Suzuki-Miyaura and Buchwald-Hartwig reactions, streamlining access to functionalized derivatives for drug discovery applications.

Application

8-Methyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its robust pyridine-triazole fusion offers enhanced metabolic stability and favorable π-stacking interactions. The amine functionality facilitates direct derivatization via coupling reactions, while the methyl group provides steric and electronic modulation. Bench-stable and compatible with standard purification methods, it functions effectively in parallel synthesis campaigns and structure-activity studies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   56.21
  • LogP   0.61992
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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