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CS-W001157 4
Total: USD 88.00

5-Bromo-2-chloro-1,3-thiazole-4-carboxylic acid

  • CAS No. 103878-60-0

  • Cat. No. CS-0215352
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-chloro-1,3-thiazole-4-carboxylic acid|CS-0215352

Structure of 103878-60-0

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General Information

  • CAS No. 103878-60-0
  • Cat. No. CS-0215352
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄HBrClNO₂S
  • Molecular Weight 242.48
  • Synonym(s) 5-BroMo-2-chlorothiazole-4-carboxylic acid
  • SMILES C1(=C(Br)SC(=N1)Cl)C(=O)O

Description

5-Bromo-2-chloro-1,3-thiazole-4-carboxylic acid features a dual halogenated thiazole core with orthogonal reactivity at C5 and C2, enabling selective functionalization. The carboxylic acid group provides a polar anchor for conjugation, while the electron-deficient heterocycle enhances electrophilic coupling efficiency. This scaffold exhibits excellent stability under standard bench conditions and serves as a key intermediate in the synthesis of bioactive heterocycles.

Application

5-Bromo-2-chloro-1,3-thiazole-4-carboxylic acid serves as a versatile building block for the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its orthogonal halogenation pattern enables selective cross-coupling reactions, including Suzuki-Miyaura and Stille couplings, while the carboxylic acid group facilitates derivatization via amide or ester formation. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.2572
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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