tert-Butyl (4-fluoropyridin-2-yl)carbamate

Name: tert-Butyl (4-fluoropyridin-2-yl)carbamate
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CAS No. 1237535-76-0
Cat. No. CS-0036406
Purity≥97%
MDL No.None

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tert-Butyl (4-fluoropyridin-2-yl)carbamate|CS-0036406

Structure of 1237535-76-0

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General Information

CAS No. 1237535-76-0
Cat. No. CS-0036406
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₃FN₂O₂
Molecular Weight 212.22
Synonym(s) tert-butyl N-(4-fluoropyridin-2-yl)carbamate
SMILES CC(C)(C)OC(=O)NC1=CC(=CC=N1)F

Description

tert-Butyl (4-fluoropyridin-2-yl)carbamate delivers a fluorinated pyridine scaffold with enhanced stability and solubility. This bench-stable carbamate integrates readily into synthetic sequences, enabling efficient access to functionalized heterocycles. The para-fluoro substitution facilitates downstream coupling reactions, while the tert-butoxycarbonyl group provides orthogonal protection for nitrogen-based transformations under standard conditions.

Application

tert-Butyl (4-fluoropyridin-2-yl)carbamate serves as a versatile building block in medicinal chemistry, enabling efficient introduction of the 4-fluoropyridin-2-yl group into target molecules. The carbamate functionality provides excellent bench stability and facilitates selective deprotection under mild acidic conditions. It reacts reliably with nucleophiles and participates in standard cross-coupling reactions, making it ideal for constructing heterocyclic scaffolds and functionalized intermediates in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P302+P352

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Computational Chemistry Data

TPSA 51.22
LogP 2.5677
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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tert-Butyl (4-fluoropyridin-2-yl)carbamate

CAS No. 1237535-76-0

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