tert-Butyl 4-(2-ethoxy-2-oxoethyl)-4-fluoropiperidine-1-carboxylate

Name: tert-Butyl 4-(2-ethoxy-2-oxoethyl)-4-fluoropiperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 1235842-48-4
Cat. No. CS-0048263
Purity≥95%
MDL No.None

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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tert-Butyl 4-(2-ethoxy-2-oxoethyl)-4-fluoropiperidine-1-carboxylate|CS-0048263

Structure of 1235842-48-4

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General Information

CAS No. 1235842-48-4
Cat. No. CS-0048263
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₂₄FNO₄
Molecular Weight 289.34
Synonym(s) tert-butyl 4-((ethoxycarbonyl)Methyl)-4-fluoropiperidine-1-carboxylate
SMILES CCOC(=O)CC1(F)CCN(CC1)C(=O)OC(C)(C)C

Description

tert-Butyl 4-(2-ethoxy-2-oxoethyl)-4-fluoropiperidine-1-carboxylate features a fluorinated piperidine core with a strategically positioned ethoxy carbonyl handle, enabling efficient downstream functionalization. The tert-butyl ester group provides enhanced stability and ease of deprotection under mild conditions. This scaffold integrates readily into bioactive molecule synthesis, particularly in medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.

Application

tert-Butyl 4-(2-ethoxy-2-oxoethyl)-4-fluoropiperidine-1-carboxylate serves as a versatile building block for fluorinated piperidine scaffolds, enabling efficient access to bioactive molecules through orthogonal functionalization. The ester and carbamate groups facilitate selective transformations, while the tert-butylcarbamate provides stable protection under standard reaction conditions. Its bench-stable nature and compatibility with diverse coupling and reduction protocols make it ideal for medicinal chemistry campaigns requiring fluorinated heterocycles.

Synthesis

Route1
- 401811-97-0
- ~%
- In-stock
  
  1235842-48-4
References
- N.V. Organon Patent: US2010/184761 A1, 2010 ; Location in patent: Page/Page column 31 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 55.84
LogP 2.6788
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Ester

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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tert-Butyl 4-(2-ethoxy-2-oxoethyl)-4-fluoropiperidine-1-carboxylate

CAS No. 1235842-48-4

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