Lot numbers can be found on the outside label of a product:
Thiazol-4-ylcarbamic acid tert-butyl ester
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CAS No. 1235406-42-4
- Cat. No. CS-B0999
- Purity≥95%
- MDL No.MFCD18800853
*For research and further manufacturing use only, not for direct human use.
Structure of 1235406-42-4
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General Information
- CAS No. 1235406-42-4
- Cat. No. CS-B0999
- Purity ≥95%
- MDL No. MFCD18800853
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₁₂N₂O₂S
- Molecular Weight 200.26
- Synonym(s) tert-Butyl thiazol-4-ylcarbamate
- SMILES O=C(NC1=CSC=N1)OC(C)(C)C
Description
Thiazol-4-ylcarbamic acid tert-butyl ester features a robust tert-butyl carbamate protecting group that enables stable handling and selective deprotection under mild conditions. The thiazole core provides a rigid, electron-deficient scaffold ideal for coupling reactions in medicinal chemistry and peptide conjugation workflows.
Application
Thiazol-4-ylcarbamic acid tert-butyl ester serves as a versatile building block for thiazole-based scaffolds in medicinal chemistry. The tert-butyl carbamate group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. It functions effectively in coupling reactions, enabling direct incorporation into peptide-like architectures or as a precursor for functionalized heterocycles via standard amine-alcohol or amine-carbon coupling protocols.
Synthesis
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Route1
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In-stock
3973-08-8 -
75-65-0 - ~93%
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In-stock
1235406-42-4
References
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MERCK PATENT GESELLSCHAFT MIT BESCHRANKER HAFTING Patent: US2012/252759 A1, 2012 ; Location in patent: Page/Page column 22 ;
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Route2
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In-stock
766-98-3 -
1258934-68-7 - ~10%
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In-stock
1235406-42-4
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1258934-71-2
References
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Synthesis, , # 18 p. 3152 - 3162
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Route3
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In-stock
766-98-3
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1258934-68-7
- ~%
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In-stock
1235406-42-4
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1258934-72-3
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1258934-71-2
References
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Synthesis, , # 18 p. 3152 - 3162
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 51.22
- LogP 2.4901
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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